What is Peyronie's disease? Share your Peyronie's disease experience Andropeyronie penis extender Visit my Peyronie's shop

L-Arginine For Peyronie's Disease

In this article, I look at the benefits, side effects and results from using L-Arginine for Peyronie's disease.

Clinical trials have not shown the effectiveness of using L-Arginine for treating Peyronie's disease. However, there is an indication that L-Arginine may help with erection quality and as such may benefit Peyronie's patients that suffer from some form of erectile dysfunction.

What Is L-Arginine?

Now Food L-Arginine

L-Arginine is naturally occurring semi-essential amino acid that converts in the body into a chemical called nitric oxide. Nitric oxide causes the blood vessels to open wider for improved blood flow.

Understandably, L-Arginine is commonly used for heart and blood vessel conditions, like congestive heart failure, chest pain and high blood pressure.

It has also been used to treat some form of erectile dysfunction, i.e. to improve the erection quality.

How Does L-Arginine Peyronie's Treatment Work?

L-Arginine is believed to prevent scaring, though there is no evidence it can reverse a scar that has already formed (like is the case with the Peyronie's disease). L-Arginine may therefore be more beneficial in improving erection quality for men with Peyronie's disease.

L-Arginine is available over-the-counter and the recommended Peyronie's L-Arginine dosage is 1 gram (1,000mg), twice a day.

What Are The L-Arginine Benefits?

L-Arginine is convenient and relatively inexpensive and safe Peyronie's treatment option.

What Are The L-Arginine Side Effects?

L-Arginine is considered safe when used in recommended dosage for short periods.

Possible L-Arginine side effects may include abdominal pain, diarrhea, blood abnormalities, low blood pressure and worsening of allergies or asthma.

Is There Any Risk Involved
In L-Arginine Treatment For Peyronie's Disease?

L-Arginine can interact with other medication. You should not take L-Arginine if you are on medication to treat high blood pressure (Antihypertensive drugs) or to increase the blood flow to the heart (Nitrates).

You should also be cautious using L-Arginine if you are using Viagra as both medicines lower the blood pressures. Too low blood pressure can cause dizziness and other side effects.

I have seen some recommend so-called PAV cocktail, i.e. combination of Pentox, L-Arginine and Viagra. I would be very careful in mixing any medication without consulting my doctor first.

Men with diabetes and men that have suffered heart attack should also avoid L-Arginine.

The Results Of Using L-Arginine For Peyronie's Disease

I have not seen any convincing testimonies that L-Arginine works well for treating Peyronie's disease, i.e. to reduce penile curvature, penis pain or plaque size. I have however seen some claim that L-Arginine improves their erection quality.

Most men that use it seem to use it in conjunction with other Peyronie's treatments, even other oral treatments. This makes it difficult to evaluate the results of using L-Arginine for Peyronie's disease.

Scientific Support
For L-Arginine Treatment For Peyronie's Disease

Clinical trials have shown no evidence of the effectiveness of using L-Arginine for treating Peyronie's disease as such.

There are however some studies indicating that L-Arginine may benefit some men with erectile dysfunction. The most notable one was published 1999 in the British Journal Of Urology International and concluded:

Oral administration of L-arginine in high doses seems to cause significant subjective improvement in sexual function in men with organic ED only if they have decreased NOx excretion or production. The haemodynamics of the corpus cavernosum were not affected by oral L-arginine at the dosage used(British Journal Of Urology International - 1999 Opens in new window symbol)

Another study indicates that L-Arginine may benefit men with erectile dysfunction if it is used with Pycnogenol:

We conclude that oral administration of L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with ED without any side effects(PubMed 2003 Opens in new window symbol)

While the third study concludes that:

Oral L-arginine 3 x 500 mg/day is not better than placebo as a first-line treatment for mixed-type impotence(PubMed 1999 Opens in new window symbol)

My Personal Experience
And Opinion Of Using L-Arginine For Peyronie's

I do not have personal experience of using L-Arginine for Peyronie's disease but I would definitely consider using L-Arginine if my Peyronie's were resulting in erectile dysfunction. Furthermore...

Dr. Levine, one of the best-known Peyronie's specialists in the world today, recommends Three Approach Nonsurgical Treatments for his patients that include the use of L-Arginine and Pentoxifylline in conjunction with Verapamil injections and using penis traction device.

Where Can I Buy L-Arginine?

You buy the L-Arginine from Amazon. I recommend buying either 500mg or 1,000mg capsules. If you buy the 500mg capsules then you need to take 2 capsules twice a day.

Below is my recommended for L-Arginine capsules from the Now Foods brand, which you can buy from Amazon.


Have you used L-Arginine in your fight against the Peyronie's disease?

If so, please use the form below and leave your Comments , or relevant practical advice to other Peyronie's sufferers.

comment on this article

Please note that all fields followed by an asterisk (*) must be filled in.

Note that only the Display name will be shown with your comment.



Please enter the word that you see below.

Captcha submission challenge   


All comments are moderated and must comply with my Commenting Rules. I will send you an email notification when your comment has been published, so please ensure your email address is valid and correct.

Shopping cart trolley Cart: item(s) | View Cart

Hello, I'm Birgir

This website is based on my experience of Peyronie's disease